BME365R: Quantitative Engineering Physiology I

Unique Number: 13420

http://www.engr.utexas.edu/bme/faculty/richards-kortum/BME365

Course Description: BME 356R and 365S provide a two-semester overview of human systems physiology, including: basic cellular physiology, neuromuscular, cardiovascular, respiratory, renal and gastro-intestinal physiology. A quantitative, model-oriented approach to physiological systems is stressed.

Pre-requisites: Biology 205L or 206L; Chemistry 369; Biomedical Engineering 314.

Times & Location: TTH 12:30 to 2:00 ETC 2.108

Textbooks: Human Physiology, Dee Silverthorn

Problem Solving in Physiology, Joel Michael and Allen Rovick

Course Instructor: Teaching Assistants:

Rebecca Richards-Kortum, PhD Cheryl Goodwin, ENS 618

Professor of Biomedical Engineering cjg@mail.utexas.edu

ENS Room 8 Office Hours: MW 1:00-2:30

kortum@mail.utexas.edu Discussion: TH 4:00-5:00 ENS 611

Office Hours: T TH 2:00-3:00 or by appointment

Kevin Terry, BEL 540

lionslife@mail.utexas.edu

Office Hours: MF 9:00-10:30

Discussion: M11:00-12:00 ENS 611

Mohammed Rahman, ENS 10

rahmanms@mail.utexas.edu

Office Hours: MTW 10:00-11:00

Discussion: M 4:00-5:00 ENS 611

Discussion Sessions: Each week the TAs will hold three optional discussion sessions; students will have opportunity to ask questions about HW and course material. Discussion sections are held in ENS 611.

Topical Outline:

I. Cellular Physiology

a. Introduction to Physiology

b. Introduction to Modeling and Review of Electric Circuits

c. Review of Cellular Physiology

d. Cellular Metabolism and Kinetics

e. Membrane Dynamics

f. Ion Transport and Cellular Homeostasis

g. The Resting Potential

h. Regulation of Cell Function and Cell Cycle Control

i. Pathophysiology: Neoplasia

j. Biomedical Application: DNA Micro-Arrays

II. Neuromuscular Physiology

a. Review of Nervous System

b. The Action Potential

c. BME Device: Patch Clamp

d. Propagation of Action Potentials

e. Skeletal Muscle

f. Neuromuscular Junction & Synaptic Transmission

g. Smooth Muscle

h. Pathophysiology: Demyelinating Diseases

III. Cardiovascular Physiology

a. Review of Cardiovascular Physiology

b. The EKG

c. Pathophysiology: Arrhythmias

d. Biomedical Device: Defibrillation

e. Pressure Volume Relationships

f. Models of Circulation, Cardiac Output, Cardiac Regulation

g. Pathophysiology: Myocardial Infarction

h. Biomedical Device: LVAD

Homework: Homework assignments are due weekly at the beginning of class on Tuesday. Late assignments will not be accepted. Homework should be your own, but general methods of working problems may be discussed with others. You may drop your lowest HW grade.

Exams: Three exams and a comprehensive final exam will be given in class.

Project: Students will work in groups of 3-4 to create an interactive web-based tutorial presenting one area of quantitative physiology in detail. Projects must include: 1) review of physiology and pathophysiology, 2) quantitative model with references to literature, and 3) discussion of clinical relevance of the work with references to literature. The top five projects will be presented in class.

Grading: Final grades will be based on performance on the homework, hour exams and final. The weight of each in determining your grade will be as follows:

Project 10%

HW 20%

Exams 1-3 15% each

Final Exam 25%

Total 100%

The lowest hour exam score can be replaced with the score on the final exam if it is to the student’s advantage. No makeup exams will be given. If you believe that a mistake has been made in grading your homework or exam, you have ONE WEEK after it has been handed back to request a re-grade in writing. After one week has passed we will not consider any requests to re-grade your work.

Drop Policy: The last day to drop this course without permission from the Dean is the fourth class day. After this day, drops are not approved unless students can demonstrate "good cause", i.e. health or personal problems that did not exist at the end of the official add & drop period.

Academic

Dishonesty: Cheating will be dealt with in as severe a manner as possible - REALLY! Cheating includes, but is not limited to, plagiarism, copying other students' homework, copying other students' exams, and obtaining copies of exams before they are given.

Evaluation: Course will be evaluated using standard UT course/instructor evaluation forms.

Daily Lecture and Assignment Schedule

Day	Date	Lecture Topic	Silverthorn Reading	Assignments Due
		UNIT 1:  Cellular Physiology
TH	8/26	Introduction to Physiology	p. 1-14, 50-79
T	8/31	Introduction to Modeling Review of Electrical Circuits		HW1
TH	9/2	Cellular Metabolism and Kinetics	p. 84-118
T	9/7	Membrane Dynamics	p. 124-149	HW2
TH	9/9	Ion Transport and Cellular Homeostasis	p. 150-164
T	9/14	The Resting Potential	p. 246-250	HW3
TH	9/16	Regulation of Cell Function Cell Cycle Control
T	9/21	Pathophysiology: Neoplasia		HW4
TH	9/23	Biomedical App: DNA Micro-Arrays
T	9/28	Exam I
		UNIT 2: Neuromuscular Physiology
TH	9/30	Review of Nervous System	p. 240-246
T	10/5	The Action Potential BME Device: Patch Clamp	p. 250-277	HW5
TH	10/7	Propagation of Action Potentials
T	10/12	Skeletal Muscle		HW6
TH	10/14	Neuromuscular Junction Synaptic Transmission	p. 389-412
T	10/19	Smooth Muscle		HW7
TH	10/21	Pathophys: Demyelinating Diseases	p. 413-420
T	10/26	Exam II
		UNIT 3: Cardiovascular Physiology
TH	10/28	Review of Cardiovascular Physiology	p. 448-468
T	11/2	The EKG I	p. 468-476	HW8
TH	11/4	The EKG II Pathophysiology: Arrhythmias Biomedical Device: Defibrillation	p. 477-484
T	11/9	Pressure Volume Relationships		HW9
TH	11/11	Models of Circulation Cardiac Output Cardiac Regulation	p. 490-512	Projects Due
T	11/16	Pathophysiology: Myocardial Infarction	p. 512-514	HW10
TH	11/18	Biomedical Device: LVAD
T	11/23	Exam III
TH	11/25	Thanksgiving Holiday
T	11/30	Project Presentation
TH	12/2	Review for Final Exam
Sat	12/11	FINAL EXAM 9 am - Noon