George
Georgiou, PhD
Professor,
Joan and Keys Curry/Cullen Trust Endowed Chair
| Office: |
CPE 4.410 |
Mailing Address: |
| Phone: |
(512) 471-6975 |
The University of Texas at Austin |
| Fax: |
(512) 471-7963 |
Department of Chemical Engineering |
| Email: |
gg@che.utexas.edu |
1 University Station C0400 |
| UT Mail: |
C0400 |
Austin, TX 78712-0231 |
Research Web Site
Presentation made to prospective graduate students 2005
Educational
Qualifications:
Ph. D., Chemical Engineering, Cornell University, 1987
M.S., Chemical Engineering, Cornell University, 1983
B.Sc., Chemical Engineering, University of Manchester Institute
of Science and Technology (UMIST), England, 1981
Awards:
Dow
Young Faculty Award (1989)
Presidential
Young Investigator Award, National Science Foundation (1987)
E.
Bergman Award, US-Israel Science Foundation (1995)
Professional
Progress Award for Outstanding Progress in Chemical Engineering,
American Institute of Chemical Engineering (2003)
University
Cooperative Society's Research Excellence Award for Best
Paper, University of Texas , Austin (2003)
Marvin
J. Johnson Award in Microbial and Biochemical Technology, American
Chemical Society (2003)
Focus:
Biotechnology
Research
[Georgiou
Molecular Bioengineering Labs]:
Our group employs
molecular biology and genetic approaches for the design
and production of proteins with improved function and for
the engineering of cellular physiology. Current research
projects include: (1) Development of new technologies to
aid protein engineering and drug discovery; (2) Engineering
of therapeutic and diagnostic antibodies; (3) Engineering
of novel enzymes; (4) The mechanism of oxidative protein
folding in bacteria; (5) Protein secretion pathways in bacteria;
(6) Regulation of RNA turnover; (7) Biologically templated
nanomaterials.
Selected
Publications
Masip, L. Pan,
J., Haldar, S., Penner-Hahn, J.A., Delisa,
M.P., Georgiou, G., Bardwell, J.C.A. and J.F. Collet,
“Engineering a de novo Pathway for the Formation of Protein
Disulfide Bonds in Bacteria,” Science 304:1185-190
(2004).
Mao, C., Solis, D.J., Reiss, B.D., Kottmann, S.T.,
Sweeney, R.Z., Hayhurst, A., Georgiou G., Iverson, B.L.
and A.M. Belcher, “Virus-Based Toolkit for the Directed
Synthesis of Magnetic and Semiconducting Nanowires,” Science
303:213-17 (2004).
Kawarasaki, Y., Griswold, K.E., Selzer, T.,
Benkovic, S.J., Iverson, B.L. and G. Georgiou “Enhanced
Crossover SCRATCHY: Construction and High-throughput
Screening of a Combinatorial Library Containing Multiple
Non-Homologous Crossovers,” Nucleic Acid Res. 31:E126 (2003).
Lee, K., Zhan X., Gao, J. Qiu, J., Feng, Y., Meganathan,
R., Cohen, S.N. and G. Georgiou, “RraA: A Protein Inhibitor
of RNase E activity that Globally Modulates RNA Abundance
in E. coli,” Cell 114:623-644 (2003).
Georgiou G. and L. Masip, “An Overoxidation Journey with
a Return Ticket,” Science 300: 592-594 (2003).
Delisa, M. P., Tullman, D. and G. Georgiou, “Folding
Quality Control in the Export of Proteins via the Bacterial
Twin Arginine Translocation Pathway” Proc. Natl. Acad. Sci.
U.S.A. 100: 6115-20 (2003).
Hayhurst, A., Happe, S., Mabry, R., Koch, Z., Iverson, B.L.
and G. Georgiou, “Isolation and Expression of Recombinant
Antibody Fragments to the Biological Warfare Pathogen Brucella
melitensis” J. Immunol. Methods 276:185-196 (2003).
Georgiou, G., “How to Flip a (Redox) Switch” Cell 111: 607-610
(2002).
Maynard, J.A., Leppla, S.H., Bratt, K., Patterson, J.L.,
Iverson, B.L. and G. Georgiou, “Protection Against Anthrax
Toxin by Recombinant Antibody Fragments Correlates with
Antigen Affinity”, Nature Biotechnology 20:577-601 (2002).
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